About E3 SUMO-protein ligase PIAS1
E3 SUMO-protein ligase PIAS1 (PIAS1) is a protein
from Homo sapiens identified by UniProt accession
O75925, 651 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | E3 SUMO-protein ligase PIAS1 |
|---|
| UniProt accession | O75925 |
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| Gene | PIAS1 |
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| Organism | Homo sapiens |
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| Length | 651 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (118)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.29
- lymphocyte count · score 0.29
- hemoglobin measurement · score 0.28
- nephronophthisis · score 0.26
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.25
- platelet crit · score 0.25
- insulin like growth factor measurement · score 0.24
- glioblastoma multiforme · score 0.24
- sex hormone-binding globulin measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75925-F1 | alphafold | PREDICTED | 68.34 | — |
Amino-acid sequence (651 residues)
MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL YRRRFPQKIM TPADLSIPNV HSSPMPATLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL ELPHLTSALH PVHPDIKLQK LPFYDLLDEL IKPTSLASDN SQRFRETCFA FALTPQQVQQ ISSSMDISGT KCDFTVQVQL RFCLSETSCP QEDHFPPNLC VKVNTKPCSL PGYLPPTKNG VEPKRPSRPI NITSLVRLST TVPNTIVVSW TAEIGRNYSM AVYLVKQLSS TVLLQRLRAK GIRNPDHSRA LIKEKLTADP DSEIATTSLR VSLLCPLGKM RLTIPCRALT CSHLQCFDAT LYIQMNEKKP TWVCPVCDKK APYEHLIIDG LFMEILKYCT DCDEIQFKED GTWAPMRSKK EVQEVSASYN GVDGCLSSTL EHQVASHHQS SNKNKKVEVI DLTIDSSSDE EEEEPSAKRT CPSLSPTSPL NNKGILSLPH QASPVSRTPS LPAVDTSYIN TSLIQDYRHP FHMTPMPYDL QGLDFFPFLS GDNQHYNTSL LAAAAAAVSD DQDLLHSSRF FPYTSSQMFL DQLSAGGSTS LPTTNGSSSG SNSSLVSSNS LRESHSHTVT NRSSTDTASI FGIIPDIISL D
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