About E3 SUMO-protein ligase PIAS2
E3 SUMO-protein ligase PIAS2 (PIAS2) is a protein
from Homo sapiens identified by UniProt accession
O75928, 621 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | E3 SUMO-protein ligase PIAS2 |
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| UniProt accession | O75928 |
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| Gene | PIAS2 |
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| Organism | Homo sapiens |
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| Length | 621 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (135)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- endometrial cancer · score 0.26
- breast adenocarcinoma · score 0.26
- ovarian cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.15
- self reported educational attainment · score 0.11
- creatinine measurement · score 0.11
- heel bone mineral density · score 0.09
- azoospermia · score 0.08
- partial chromosome Y deletion · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75928-F1 | alphafold | PREDICTED | 70.52 | — |
Amino-acid sequence (621 residues)
MADFEELRNM VSSFRVSELQ VLLGFAGRNK SGRKHDLLMR ALHLLKSGCS PAVQIKIREL YRRRYPRTLE GLSDLSTIKS SVFSLDGGSS PVEPDLAVAG IHSLPSTSVT PHSPSSPVGS VLLQDTKPTF EMQQPSPPIP PVHPDVQLKN LPFYDVLDVL IKPTSLVQSS IQRFQEKFFI FALTPQQVRE ICISRDFLPG GRRDYTVQVQ LRLCLAETSC PQEDNYPNSL CIKVNGKLFP LPGYAPPPKN GIEQKRPGRP LNITSLVRLS SAVPNQISIS WASEIGKNYS MSVYLVRQLT SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK MRLTIPCRAV TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD GLFMEILNDC SDVDEIKFQE DGSWCPMRPK KEAMKVSSQP CTKIESSSVL SKPCSVTVAS EASKKKVDVI DLTIESSSDE EEDPPAKRKC IFMSETQSSP TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT DYSVPFHHTP ISSMSSDLPG LDFLSLIPVD PQYCPPMFLD SLTSPLTASS TSVTTTSSHE SSTHVSSSSS RSETGVITSS GSNIPDIISL D
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