About Pre-mRNA-splicing factor SPF27
Pre-mRNA-splicing factor SPF27 (BCAS2) is a protein
from Homo sapiens identified by UniProt accession
O75934, 225 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Pre-mRNA-splicing factor SPF27 |
|---|
| UniProt accession | O75934 |
|---|
| Gene | BCAS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 225 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- cystatin C measurement · score 0.13
- platelet component distribution width · score 0.10
- mean platelet volume · score 0.09
- non-small cell lung carcinoma · score 0.07
- breast cancer · score 0.06
- myeloid white cell count · score 0.03
- cancer · score 0.02
- Microcephaly · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75934-F1 | alphafold | PREDICTED | 88.90 | — |
Amino-acid sequence (225 residues)
MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL SYLTAPDYSA FETDIMRNEF ERLAARQPIE LLSMKRYELP APSSGQKNDI TAWQECVNNS MAQLEHQAVR IENLELMSQH GCNAWKVYNE NLVHMIEHAQ KELQKLRKHI QDLNWQRKNM QLTAGSKLRE MESNWVSLVS KNYEIERTIV QLENEIYQIK QQHGEANKEN IRQDF
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