About Dynactin subunit 3
Dynactin subunit 3 (DCTN3) is a protein
from Homo sapiens identified by UniProt accession
O75935, 186 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Dynactin subunit 3 |
|---|
| UniProt accession | O75935 |
|---|
| Gene | DCTN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 186 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.05
- diastolic blood pressure · score 0.04
- blood protein measurement · score 0.04
- testosterone measurement · score 0.03
- appendicular lean mass · score 0.03
- adolescent idiopathic scoliosis · score 0.03
- aspartate aminotransferase measurement · score 0.02
- hypertension · score 0.02
- neoplasm · score 0.01
- Alzheimer disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75935-F1 | alphafold | PREDICTED | 88.35 | — |
Amino-acid sequence (186 residues)
MAGLTDLQRL QARVEELERW VYGPGGARGS RKVADGLVKV QVALGNISSK RERVKILYKK IEDLIKYLDP EYIDRIAIPD ASKLQFILAE EQFILSQVAL LEQVNALVPM LDSAHIKAVP EHAARLQRLA QIHIQQQDQC VEITEESKAL LEEYNKTTML LSKQFVQWDE LLCQLEAATQ VKPAEE
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