About DnaJ homolog subfamily C member 8
DnaJ homolog subfamily C member 8 (DNAJC8) is a protein
from Homo sapiens identified by UniProt accession
O75937, 253 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | DnaJ homolog subfamily C member 8 |
|---|
| UniProt accession | O75937 |
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| Gene | DNAJC8 |
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| Organism | Homo sapiens |
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| Length | 253 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- aspartate aminotransferase measurement · score 0.27
- hematocrit · score 0.27
- hemoglobin measurement · score 0.26
- hair color · score 0.19
- serum alanine aminotransferase measurement · score 0.18
- creatinine measurement · score 0.18
- eosinophil count · score 0.14
- eosinophil percentage of leukocytes · score 0.14
- Blackfan-Diamond anemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75937-F1 | alphafold | PREDICTED | 83.73 | — |
Amino-acid sequence (253 residues)
MAASGESGTS GGGGSTEEAF MTFYSEVKQI EKRDSVLTSK NQIERLTRPG SSYFNLNPFE VLQIDPEVTD EEIKKRFRQL SILVHPDKNQ DDADRAQKAF EAVDKAYKLL LDQEQKKRAL DVIQAGKEYV EHTVKERKKQ LKKEGKPTIV EEDDPELFKQ AVYKQTMKLF AELEIKRKER EAKEMHERKR QREEEIEAQE KAKREREWQK NFEESRDGRV DSWRNFQANT KGKKEKKNRT FLRPPKVKME QRE
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