About Cell cycle checkpoint protein RAD17
Cell cycle checkpoint protein RAD17 (RAD17) is a protein
from Homo sapiens identified by UniProt accession
O75943, 681 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Cell cycle checkpoint protein RAD17 |
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| UniProt accession | O75943 |
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| Gene | RAD17 |
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| Organism | Homo sapiens |
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| Length | 681 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (120)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.32
- head and neck squamous cell carcinoma · score 0.30
- breast adenocarcinoma · score 0.28
- interleukin 18 measurement · score 0.26
- gastric adenocarcinoma · score 0.23
- depressive disorder · score 0.21
- clear cell renal carcinoma · score 0.21
- ovarian serous adenocarcinoma · score 0.19
- lung carcinoma · score 0.19
- small cell lung carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75943-F1 | alphafold | PREDICTED | 68.88 | — |
Amino-acid sequence (681 residues)
MSKTFLRPKV SSTKVTDWVD PSFDDFLECS GVSTITATSL GVNNSSHRRK NGPSTLESSR FPARKRGNLS SLEQIYGLEN SKEYLSENEP WVDKYKPETQ HELAVHKKKI EEVETWLKAQ VLERQPKQGG SILLITGPPG CGKTTTLKIL SKEHGIQVQE WINPVLPDFQ KDDFKGMFNT ESSFHMFPYQ SQIAVFKEFL LRATKYNKLQ MLGDDLRTDK KIILVEDLPN QFYRDSHTLH EVLRKYVRIG RCPLIFIISD SLSGDNNQRL LFPKEIQEEC SISNISFNPV APTIMMKFLN RIVTIEANKN GGKITVPDKT SLELLCQGCS GDIRSAINSL QFSSSKGENN LRPRKKGMSL KSDAVLSKSK RRKKPDRVFE NQEVQAIGGK DVSLFLFRAL GKILYCKRAS LTELDSPRLP SHLSEYERDT LLVEPEEVVE MSHMPGDLFN LYLHQNYIDF FMEIDDIVRA SEFLSFADIL SGDWNTRSLL REYSTSIATR GVMHSNKARG YAHCQGGGSS FRPLHKPQWF LINKKYRENC LAAKALFPDF CLPALCLQTQ LLPYLALLTI PMRNQAQISF IQDIGRLPLK RHFGRLKMEA LTDREHGMID PDSGDEAQLN GGHSAEESLG EPTQATVPET WSLPLSQNSA SELPASQPQP FSAQGDMEEN IIIEDYESDG T
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