NALCN channel auxiliary factor 2 (NALF2)

About NALCN channel auxiliary factor 2

NALCN channel auxiliary factor 2 (NALF2) is a protein from Homo sapiens identified by UniProt accession O75949, 472 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	NALCN channel auxiliary factor 2
UniProt accession	O75949
Gene	NALF2
Organism	Homo sapiens
Length	472 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.03
Tetralogy of Fallot · score 0.03
chronotype measurement · score 0.03
actinic keratosis · score 0.01
Ataxia-telangiectasia · score 0.01
Neurodevelopmental delay · score 0.01
ulcerative colitis · score 0.01
systemic lupus erythematosus · score 0.01
neoplasm · score 0.00
Granulomatosis with Polyangiitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75949-F1	alphafold	PREDICTED	63.37	—

Amino-acid sequence (472 residues)

MFRGAWMWPG KDAAALTICC CCCCWAPRPS DKPCADSERA QRWRLSLASL LFFTVLLADH LWLCAGARPR ARELSSAMRP PWGAGRERQP VPPRAVLPLP PPPPGEPSAP PGTCGPRYSN LTKAAPAAGS RPVCGGVPEP TGLDAACTKL QSLQRLFEPT TPAPPLRPPD SLSRAPAEFP SAKKNLLKGH FRNFTLSFCD TYTVWDLLLG MDRPDSLDCS LDTLMGDLLA VVASPGSGAW EACSNCIEAY QRLDRHAQEK YDEFDLVLHK YLQAEEYSIR SCTKGCKAVY KAWLCSEYFS VTQQECQRWV PCKQYCLEVQ TRCPFILPDN EEMVYGGLPG FICTGLLDTS PKRLETKCCD VQWVSCEAKK KKFKESEAPK THQQQFHHSY FHHYHQQYHH YHPHHDPPGR VSNKPALLPV SGGSRLSPSR IRLCVLVLML LHTVVSFSSN QGGGGLGLET LPALEEGLTR EE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards