About Calcium-binding tyrosine phosphorylation-regulated protein
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) is a protein
from Homo sapiens identified by UniProt accession
O75952, 493 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Calcium-binding tyrosine phosphorylation-regulated protein |
|---|
| UniProt accession | O75952 |
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| Gene | CABYR |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.12
- neutrophil count · score 0.10
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- protein measurement · score 0.08
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 49 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75952-F1 | alphafold | PREDICTED | 47.83 | — |
Amino-acid sequence (493 residues)
MISSKPRLVV PYGLKTLLEG ISRAVLKTNP SNINQFAAAY FQELTMYRGN TTMDIKDLVK QFHQIKVEKW SEGTTPQKKL ECLKEPGKTS VESKVPTQME KSTDTDEDNV TRTEYSDKTT QFPSVYAVPG TEQTEAVGGL SSKPATPKTT TPPSSPPPTA VSPEFAYVPA DPAQLAAQML GKVSSIHSDQ SDVLMVDVAT SMPVVIKEVP SSEAAEDVMV AAPLVCSGKV LEVQVVNQTS VHVDLGSQPK ENEAEPSTAS SVPLQDEQEP PAYDQAPEVT LQADIEVMST VHISSVYNDV PVTEGVVYIE QLPEQIVIPF TDQVACLKEN EQSKENEQSP RVSPKSVVEK TTSGMSKKSV ESVKLAQLEE NAKYSSVYME AEATALLSDT SLKGQPEVPA QLLDAEGAIK IGSEKSLHLE VEITSIVSDN TGQEESGENS VPQEMEGKPV LSGEAAEAVH SGTSVKSSSG PFPPAPEGLT APEIEPEGES TAE
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