About A-kinase anchor protein 3
A-kinase anchor protein 3 (AKAP3) is a protein
from Homo sapiens identified by UniProt accession
O75969, 853 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | A-kinase anchor protein 3 |
|---|
| UniProt accession | O75969 |
|---|
| Gene | AKAP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 853 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (99)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- Male infertility due to large-headed multiflagellar polyploid spermatozoa · score 0.37
- blood phosphate measurement · score 0.26
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- breast cancer · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 49 · score 0.07
- spermatogenic failure 43 · score 0.07
- spermatogenic failure 45 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75969-F1 | alphafold | PREDICTED | 50.60 | — |
Amino-acid sequence (853 residues)
MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE KSTAEFQDVR FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE MTHKEIPCQG PRAQLGNGSS VDEVSFYANR LTNLVIAMAR KEINEKIDGS ENKCVYQSLY MGNEPTPTKS LSKIASELVN ETVSACSRNA APDKAPGSGD RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF FYKEVFESRN GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI MKTLKIQVKD TTIATILLKK VLLKHAKEVV SDLIDSFLRN LHSVTGTLMT DTQFVSAVKR TVFSHGSQKA TDIMDAMLRK LYNVMFAKKV PEHVRKAQDK AESYSLISMK GMGDPKNRNV NFAMKSETKL REKMYSEPKS EEETCAKTLG EHIIKEGLTL WHKTQQKECK SLGFQHAAFE APNTQRKPAS DISFEYPEDI GNLSLPPYPP EKPENFMYDS DSWAEDLIVS ALLLIQYHLA QGGRRDARSF VEAAGTTNFP ANEPPVAPDE SCLKSAPIVG DQEQAEKKDL RSVFFNFIRN LLSETIFKRD QSPEPKVPEQ PVKEDRKLCE RPLASSPPRL YEDDETPGAL SGLTKMAVSQ IDGHMSGQMV EHLMNSVMKL CVIIAKSCDA SLAELGDDKS GDASRLTSAF PDSLYECLPA KGTGSAEAVL QNAYQAIHNE MRGTSGQPPE GCAAPTVIVS NHNLTDTVQN KQLQAVLQWV AASELNVPIL YFAGDDEGIQ EKLLQLSAAA VDKGCSVGEV LQSVLRYEKE RQLNEAVGNV TPLQLLDWLM VNL
Explore A-kinase anchor protein 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets