SAM and SH3 domain-containing protein 3 (SASH3)

About SAM and SH3 domain-containing protein 3

SAM and SH3 domain-containing protein 3 (SASH3) is a protein from Homo sapiens identified by UniProt accession O75995, 380 residues long. MolForge cross-references it against 0 known binders and 200 disease associations.

Target properties

Protein name	SAM and SH3 domain-containing protein 3
UniProt accession	O75995
Gene	SASH3
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (200)

Diseases linked to this target (Open Targets).

immunodeficiency 102 · score 0.65
X-Linked Combined Immunodeficiency Diseases · score 0.38
inflammatory bowel disease · score 0.18
Immunodeficiency · score 0.12
cancer · score 0.08
common variable immunodeficiency · score 0.06
isolated agammaglobulinemia · score 0.06
lung adenocarcinoma · score 0.06
gamma chain deficiency · score 0.05
T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75995-F1	alphafold	PREDICTED	65.13	—

Amino-acid sequence (380 residues)

MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDDSGVP TPEDAGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM ADTLEEGSAS PTSPDYSLDS PGPEKMALAF SEQEEHELPV LSRQASTGSE LCSPSPGSGS FGEEPPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD VIQIIEKPPV GTWLGLLNGK VGSFKFIYVD VLPEEAVGHA RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG CFEGSESGRD DAELAGTEEQ LQGLSLAGAP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards