About Glutaredoxin-3
Glutaredoxin-3 (GLRX3) is a protein
from Homo sapiens identified by UniProt accession
O76003, 335 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Glutaredoxin-3 |
|---|
| UniProt accession | O76003 |
|---|
| Gene | GLRX3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 335 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (56)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.40
- mean corpuscular hemoglobin · score 0.32
- mean corpuscular hemoglobin concentration · score 0.32
- neurodegenerative disease · score 0.30
- metabolite measurement · score 0.22
- sleep duration · score 0.21
- triglyceride measurement · score 0.21
- DNA methylation · score 0.17
- adolescent idiopathic scoliosis · score 0.15
- pancreatic neoplasm · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76003-F1 | alphafold | PREDICTED | 88.65 | — |
Amino-acid sequence (335 residues)
MAAGAAEAAV AAVEEVGSAG QFEELLRLKA KSLLVVHFWA PWAPQCAQMN EVMAELAKEL PQVSFVKLEA EGVPEVSEKY EISSVPTFLF FKNSQKIDRL DGAHAPELTK KVQRHASSGS FLPSANEHLK EDLNLRLKKL THAAPCMLFM KGTPQEPRCG FSKQMVEILH KHNIQFSSFD IFSDEEVRQG LKAYSSWPTY PQLYVSGELI GGLDIIKELE ASEELDTICP KAPKLEERLK VLTNKASVML FMKGNKQEAK CGFSKQILEI LNSTGVEYET FDILEDEEVR QGLKAYSNWP TYPQLYVKGE LVGGLDIVKE LKENGELLPI LRGEN
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