Keratin, type I cuticular Ha3-I (KRT33A)

About Keratin, type I cuticular Ha3-I

Keratin, type I cuticular Ha3-I (KRT33A) is a protein from Homo sapiens identified by UniProt accession O76009, 404 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha3-I
UniProt accession	O76009
Gene	KRT33A
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.18
head and neck squamous cell carcinoma · score 0.18
ovarian cancer · score 0.18
prostate adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
esophageal cancer · score 0.14
prostate cancer · score 0.11
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76009-F1	alphafold	PREDICTED	78.93	—

Amino-acid sequence (404 residues)

MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN TFGY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards