Keratin, type I cuticular Ha4 (KRT34)

About Keratin, type I cuticular Ha4

Keratin, type I cuticular Ha4 (KRT34) is a protein from Homo sapiens identified by UniProt accession O76011, 394 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha4
UniProt accession	O76011
Gene	KRT34
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.18
head and neck squamous cell carcinoma · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14
low grade glioma · score 0.11
Hyperlipoproteinemia type 1 · score 0.05
cryptorchidism · score 0.04
Testicular regression syndrome · score 0.04
isolated congenital hypogonadotropic hypogonadism · score 0.04
familial apolipoprotein C-II deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76011-F1	alphafold	PREDICTED	79.85	—

Amino-acid sequence (394 residues)

MSYSCCLPSL GCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELEKLIQE RSQQQEPLLC PSYQSYFKTI EELQQKILCA KAENARLVVN IDNAKLASDD FRSKYQTEQS LRLLVESDIN SIRRILDELT LCKSDLESQV ESLREELICL KKNHEEEVNT LRSQLGDRLN VEVDTAPTVD LNQVLNETRS QYEALVEINR REVEQWFATQ TEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH NLRDSLENTL TESEAHYSSQ LSQVQSLITN VESQLAEIRC DLERQNQEYQ VLLDVRARLE CEINTYRSLL ESEDCKLPCN PCATTNASGN SCGPCGTSQK GCCN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards