About Keratin, type I cuticular Ha6
Keratin, type I cuticular Ha6 (KRT36) is a protein
from Homo sapiens identified by UniProt accession
O76013, 467 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Keratin, type I cuticular Ha6 |
|---|
| UniProt accession | O76013 |
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| Gene | KRT36 |
|---|
| Organism | Homo sapiens |
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| Length | 467 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- clear cell renal carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
- low grade glioma · score 0.11
- hair shape measurement · score 0.07
- focal palmoplantar and gingival keratoderma · score 0.07
- Ichthyosis-hypotrichosis syndrome · score 0.06
- keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76013-F1 | alphafold | PREDICTED | 75.73 | — |
Amino-acid sequence (467 residues)
MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL
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