Keratin, type I cuticular Ha7 (KRT37)

About Keratin, type I cuticular Ha7

Keratin, type I cuticular Ha7 (KRT37) is a protein from Homo sapiens identified by UniProt accession O76014, 449 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha7
UniProt accession	O76014
Gene	KRT37
Organism	Homo sapiens
Length	449 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.19
breast adenocarcinoma · score 0.18
hair color · score 0.12
low grade glioma · score 0.11
psoriasis · score 0.03
hair shape measurement · score 0.02
neoplasm · score 0.01
infect · score 0.01
infection · score 0.01
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76014-F1	alphafold	PREDICTED	74.40	—

Amino-acid sequence (449 residues)

MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC STPASCTSCP SCGPVTGGSP SGHGASMGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards