Keratin, type I cuticular Ha8 (KRT38)

About Keratin, type I cuticular Ha8

Keratin, type I cuticular Ha8 (KRT38) is a protein from Homo sapiens identified by UniProt accession O76015, 456 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha8
UniProt accession	O76015
Gene	KRT38
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.18
glioblastoma multiforme · score 0.18
prostate adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14
neuroblastoma · score 0.13
breast carcinoma · score 0.01
urinary bladder carcinoma · score 0.01
neoplasm · score 0.00
metastatic neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76015-F1	alphafold	PREDICTED	74.14	—

Amino-acid sequence (456 residues)

MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS TTGSRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards