About ATP-dependent clpX-like chaperone, mitochondrial
ATP-dependent clpX-like chaperone, mitochondrial (CLPX) is a protein
from Homo sapiens identified by UniProt accession
O76031, 633 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | ATP-dependent clpX-like chaperone, mitochondrial |
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| UniProt accession | O76031 |
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| Gene | CLPX |
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| Organism | Homo sapiens |
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| Length | 633 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (40)
Diseases linked to this target (Open Targets).
- protoporphyria, erythropoietic, 2 · score 0.44
- creatinine measurement · score 0.32
- neurodegenerative disease · score 0.23
- neoplasm · score 0.02
- erythropoietic protoporphyria · score 0.01
- Cowden syndrome 1 · score 0.01
- infection · score 0.01
- infect · score 0.01
- porphyria · score 0.00
- acute myeloid leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76031-F1 | alphafold | PREDICTED | 66.59 | — |
Amino-acid sequence (633 residues)
MPSCGACTCG AAAVRLITSS LASAQRGISG GRIHMSVLGR LGTFETQILQ RAPLRSFTET PAYFASKDGI SKDGSGDGNK KSASEGSSKK SGSGNSGKGG NQLRCPKCGD LCTHVETFVS STRFVKCEKC HHFFVVLSEA DSKKSIIKEP ESAAEAVKLA FQQKPPPPPK KIYNYLDKYV VGQSFAKKVL SVAVYNHYKR IYNNIPANLR QQAEVEKQTS LTPRELEIRR REDEYRFTKL LQIAGISPHG NALGASMQQQ VNQQIPQEKR GGEVLDSSHD DIKLEKSNIL LLGPTGSGKT LLAQTLAKCL DVPFAICDCT TLTQAGYVGE DIESVIAKLL QDANYNVEKA QQGIVFLDEV DKIGSVPGIH QLRDVGGEGV QQGLLKLLEG TIVNVPEKNS RKLRGETVQV DTTNILFVAS GAFNGLDRII SRRKNEKYLG FGTPSNLGKG RRAAAAADLA NRSGESNTHQ DIEEKDRLLR HVEARDLIEF GMIPEFVGRL PVVVPLHSLD EKTLVQILTE PRNAVIPQYQ ALFSMDKCEL NVTEDALKAI ARLALERKTG ARGLRSIMEK LLLEPMFEVP NSDIVCVEVD KEVVEGKKEP GYIRAPTKES SEEEYDSGVE EEGWPRQADA ANS
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