Natural cytotoxicity triggering receptor 1 (NCR1)

About Natural cytotoxicity triggering receptor 1

Natural cytotoxicity triggering receptor 1 (NCR1) is a protein from Homo sapiens identified by UniProt accession O76036, 304 residues long. MolForge cross-references it against 0 known binders and 368 disease associations.

Target properties

Protein name	Natural cytotoxicity triggering receptor 1
UniProt accession	O76036
Gene	NCR1
Organism	Homo sapiens
Length	304 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (368)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
influenza · score 0.38
blood protein measurement · score 0.26
neoplasm · score 0.11
acute lymphoblastic leukemia · score 0.08
Opioid use measurement · score 0.08
infection · score 0.08
infect · score 0.08
Obesity · score 0.08
Wiskott-Aldrich syndrome · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76036-F1	alphafold	PREDICTED	83.88	—

Amino-acid sequence (304 residues)

MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINK VQFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEKV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET GLQKDHALWD HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN TQTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards