About E3 ubiquitin-protein ligase NEURL1
E3 ubiquitin-protein ligase NEURL1 (NEURL1) is a protein
from Homo sapiens identified by UniProt accession
O76050, 574 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase NEURL1 |
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| UniProt accession | O76050 |
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| Gene | NEURL1 |
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| Organism | Homo sapiens |
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| Length | 574 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.50
- cardiac arrhythmia · score 0.39
- atrial flutter · score 0.37
- white matter hyperintensity measurement · score 0.34
- cardiac edema · score 0.30
- C-reactive protein measurement · score 0.27
- intraocular pressure measurement · score 0.24
- breast adenocarcinoma · score 0.23
- ovarian cancer · score 0.18
- low grade glioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76050-F1 | alphafold | PREDICTED | 70.21 | — |
Amino-acid sequence (574 residues)
MGNNFSSIPS LPRGNPSRAP RGHPQNLKDS IGGPFPVTSH RCHHKQKHCP AVLPSGGLPA TPLLFHPHTK GSQILMDLSH KAVKRQASFC NAITFSNRPV LIYEQVRLKI TKKQCCWSGA LRLGFTSKDP SRIHPDSLPK YACPDLVSQS GFWAKALPEE FANEGNIIAF WVDKKGRVFH RINDSAVMLF FSGVRTADPL WALVDVYGLT RGVQLLDSEL VLPDCLRPRS FTALRRPSLR READDARLSV SLCDLNVPGA DGDEAAPAAG CPIPQNSLNS QHSRALPAQL DGDLRFHALR AGAHVRILDE QTVARVEHGR DERALVFTSR PVRVAETIFV KVTRSGGARP GALSFGVTTC DPGTLRPADL PFSPEALVDR KEFWAVCRVP GPLHSGDILG LVVNADGELH LSHNGAAAGM QLCVDASQPL WMLFGLHGTI TQIRILGSTI LAERGIPSLP CSPASTPTSP SALGSRLSDP LLSTCSSGPL GSSAGGTAPN SPVSLPESPV TPGLGQWSDE CTICYEHAVD TVIYTCGHMC LCYACGLRLK KALHACCPIC RRPIKDIIKT YRSS
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