SEC14-like protein 2 (SEC14L2)

About SEC14-like protein 2

SEC14-like protein 2 (SEC14L2) is a protein from Homo sapiens identified by UniProt accession O76054, 403 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	SEC14-like protein 2
UniProt accession	O76054
Gene	SEC14L2
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
sex hormone-binding globulin measurement · score 0.24
neuroinflammatory disorder · score 0.15
hemoglobin measurement · score 0.08
open-angle glaucoma · score 0.07
white matter microstructure measurement · score 0.07
BMI-adjusted waist circumference · score 0.06
platelet component distribution width · score 0.06
calcium measurement · score 0.06
hypertriglyceridemia 2 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76054-F1	alphafold	PREDICTED	95.59	—

Amino-acid sequence (403 residues)

MSGRVGDLSP RQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ KSEAMLRKHV EFRKQKDIDN IISWQPPEVI QQYLSGGMCG YDLDGCPVWY DIIGPLDAKG LLFSASKQDL LRTKMRECEL LLQECAHQTT KLGRKVETIT IIYDCEGLGL KHLWKPAVEA YGEFLCMFEE NYPETLKRLF VVKAPKLFPV AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQVPVE YGGTMTDPDG NPKCKSKINY GGDIPRKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG CVLRWQFMSD GADVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHLVPED GTLTCSDPGI YVLRFDNTYS FIHAKKVNFT VEVLLPDKAS EEKMKQLGAG TPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards