E3 ubiquitin-protein ligase RNF8 (RNF8)

About E3 ubiquitin-protein ligase RNF8

E3 ubiquitin-protein ligase RNF8 (RNF8) is a protein from Homo sapiens identified by UniProt accession O76064, 485 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF8
UniProt accession	O76064
Gene	RNF8
Organism	Homo sapiens
Length	485 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
lung adenocarcinoma · score 0.28
glioblastoma multiforme · score 0.27
esophageal cancer · score 0.26
squamous cell lung carcinoma · score 0.23
gastric adenocarcinoma · score 0.20
mean corpuscular volume · score 0.19
mean corpuscular hemoglobin · score 0.16
urinary bladder cancer · score 0.14
small cell lung carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76064-F1	alphafold	PREDICTED	75.42	—

Amino-acid sequence (485 residues)

MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY EYEVTEEDWE TIYPCLSPKN DQMIEKNKEL RTKRKFSLDE LAGPGAEGPS NLKSKINKVS CESGQPVKSQ GKGEVASTPS DNLDPKLTAL EPSKTTGAPI YPGFPKVTEV HHEQKASNSS ASQRSLQMFK VTMSRILRLK IQMQEKHEAV MNVKKQTQKG NSKKVVQMEQ ELQDLQSQLC AEQAQQQARV EQLEKTFQEE EQHLQGLEIA QGEKDLKQQL AQALQEHWAL MEELNRSKKD FEAIIQAKNK ELEQTKEEKE KMQAQKEEVL SHMNDVLENE LQCIICSEYF IEAVTLNCAH SFCSYCINEW MKRKIECPIC RKDIKSKTYS LVLDNCINKM VNNLSSEVKE RRIVLIRERK AKRLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards