DNA fragmentation factor subunit beta (DFFB)

About DNA fragmentation factor subunit beta

DNA fragmentation factor subunit beta (DFFB) is a protein from Homo sapiens identified by UniProt accession O76075, 338 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	DNA fragmentation factor subunit beta
UniProt accession	O76075
Gene	DFFB
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.24
breast adenocarcinoma · score 0.24
hemoglobin measurement · score 0.20
reticulocyte count · score 0.18
mean corpuscular hemoglobin concentration · score 0.17
erythrocyte count · score 0.16
Red cell distribution width · score 0.16
smoking status measurement · score 0.16
red blood cell density measurement · score 0.15
protein measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76075-F1	alphafold	PREDICTED	92.65	—

Amino-acid sequence (338 residues)

MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF PSVPDNAELV LLTLGQAWQG YVSDIRRFLS AFHEPQVGLI QAAQQLLCDE QAPQRQRLLA DLLHNVSQNI AAETRAEDPP WFEGLESRFQ SKSGYLRYSC ESRIRSYLRE VSSYPSTVGA EAQEEFLRVL GSMCQRLRSM QYNGSYFDRG AKGGSRLCTP EGWFSCQGPF DMDSCLSRHS INPYSNRESR ILFSTWNLDH IIEKKRTIIP TLVEAIKEQD GREVDWEYFY GLLFTSENLK LVHIVCHKKT THKLNCDPSR IYKPQTRLKR KQPVRKRQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards