Regulator of G-protein signaling 20 (RGS20)

About Regulator of G-protein signaling 20

Regulator of G-protein signaling 20 (RGS20) is a protein from Homo sapiens identified by UniProt accession O76081, 388 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Regulator of G-protein signaling 20
UniProt accession	O76081
Gene	RGS20
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

beta-secretase 1 measurement · score 0.19
non-small cell lung carcinoma · score 0.08
pachyonychia congenita · score 0.07
renal cell carcinoma · score 0.07
age at first sexual intercourse measurement · score 0.05
neoplasm · score 0.05
high density lipoprotein cholesterol measurement · score 0.04
sleep duration · score 0.04
cerebrospinal fluid biomarker measurement · score 0.03
hepatocellular carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76081-F1	alphafold	PREDICTED	61.80	—

Amino-acid sequence (388 residues)

MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA VPDIKSFPPA QLPDSPAAPK LFGLLSSPLS SLARFFSHLL RRPPPEAPRR RLDFSPLLPA LPAARLSRGH EELPGRLSLL LGAALALPGR PSGGRPLRPP HPVAKPREED ATAGQSSPMP QMGSERMEMR KRQMPAAQDT PGAAPGQPGA GSRGSNACCF CWCCCCSCSC LTVRNQEDQR PTIASHELRA DLPTWEESPA PTLEEVNAWA QSFDKLMVTP AGRNAFREFL RTEFSEENML FWMACEELKK EANKNIIEEK ARIIYEDYIS ILSPKEVSLD SRVREVINRN MVEPSQHIFD DAQLQIYTLM HRDSYPRFMN SAVYKDLLQS LSEKSIEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards