About Organic cation/carnitine transporter 2
Organic cation/carnitine transporter 2 (SLC22A5) is a protein
from Homo sapiens identified by UniProt accession
O76082, 557 residues long.
MolForge cross-references it against 0 known binders and
282 disease associations.
Target properties
| Protein name | Organic cation/carnitine transporter 2 |
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| UniProt accession | O76082 |
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| Gene | SLC22A5 |
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| Organism | Homo sapiens |
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| Length | 557 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (282)
Diseases linked to this target (Open Targets).
- Systemic primary carnitine deficiency · score 0.87
- systemic primary carnitine deficiency disease · score 0.85
- Decreased circulating carnitine concentration · score 0.53
- genetic disorder · score 0.48
- blood metabolite measurement · score 0.41
- monocyte count · score 0.40
- platelet count · score 0.37
- serum metabolite measurement · score 0.36
- Axial hypotonia · score 0.34
- acylcarnitine measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76082-F1 | alphafold | PREDICTED | 86.52 | — |
Amino-acid sequence (557 residues)
MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFTGLSSV FLIATPEHRC RVPDAANLSS AWRNHTVPLR LRDGREVPHS CRRYRLATIA NFSALGLEPG RDVDLGQLEQ ESCLDGWEFS QDVYLSTIVT EWNLVCEDDW KAPLTISLFF VGVLLGSFIS GQLSDRFGRK NVLFVTMGMQ TGFSFLQIFS KNFEMFVVLF VLVGMGQISN YVAAFVLGTE ILGKSVRIIF STLGVCIFYA FGYMVLPLFA YFIRDWRMLL VALTMPGVLC VALWWFIPES PRWLISQGRF EEAEVIIRKA AKANGIVVPS TIFDPSELQD LSSKKQQSHN ILDLLRTWNI RMVTIMSIML WMTISVGYFG LSLDTPNLHG DIFVNCFLSA MVEVPAYVLA WLLLQYLPRR YSMATALFLG GSVLLFMQLV PPDLYYLATV LVMVGKFGVT AAFSMVYVYT AELYPTVVRN MGVGVSSTAS RLGSILSPYF VYLGAYDRFL PYILMGSLTI LTAILTLFLP ESFGTPLPDT IDQMLRVKGM KHRKTPSHTR MLKDGQERPT ILKSTAF
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