About High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A) is a protein
from Homo sapiens identified by UniProt accession
O76083, 593 residues long.
MolForge cross-references it against 0 known binders and
159 disease associations.
Target properties
| Protein name | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| UniProt accession | O76083 |
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| Gene | PDE9A |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (159)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.55
- stroke · score 0.55
- Hepatitis, Alcoholic · score 0.48
- diabetic nephropathy · score 0.47
- chronic kidney disease · score 0.47
- Myocardial Ischemia · score 0.47
- diabetes mellitus · score 0.46
- non-alcoholic steatohepatitis · score 0.45
- cardiovascular disease · score 0.44
- hemoglobin measurement · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76083-F1 | alphafold | PREDICTED | 81.01 | — |
Amino-acid sequence (593 residues)
MGSGSSSYRP KAIYLDIDGR IQKVIFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM VSIDPTMPAN SERTPYKVRP VAIKQLSAGV EDKRTTSRGQ SAERPLRDRR VVGLEQPRRE GAFESGQVEP RPREPQGCYQ EGQRIPPERE ELIQSVLAQV AEQFSRAFKI NELKAEVANH LAVLEKRVEL EGLKVVEIEK CKSDIKKMRE ELAARSSRTN CPCKYSFLDN HKKLTPRRDV PTYPKYLLSP ETIEALRKPT FDVWLWEPNE MLSCLEHMYH DLGLVRDFSI NPVTLRRWLF CVHDNYRNNP FHNFRHCFCV AQMMYSMVWL CSLQEKFSQT DILILMTAAI CHDLDHPGYN NTYQINARTE LAVRYNDISP LENHHCAVAF QILAEPECNI FSNIPPDGFK QIRQGMITLI LATDMARHAE IMDSFKEKME NFDYSNEEHM TLLKMILIKC CDISNEVRPM EVAEPWVDCL LEEYFMQSDR EKSEGLPVAP FMDRDKVTKA TAQIGFIKFV LIPMFETVTK LFPMVEEIML QPLWESRDRY EELKRIDDAM KELQKKTDSL TSGATEKSRE RSRDVKNSEG DCA
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