About Bestrophin-1
Bestrophin-1 (BEST1) is a protein
from Homo sapiens identified by UniProt accession
O76090, 585 residues long.
MolForge cross-references it against 0 known binders and
412 disease associations.
Target properties
| Protein name | Bestrophin-1 |
|---|
| UniProt accession | O76090 |
|---|
| Gene | BEST1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 585 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (412)
Diseases linked to this target (Open Targets).
- vitelliform macular dystrophy 2 · score 0.84
- autosomal recessive bestrophinopathy · score 0.82
- Best vitelliform macular dystrophy · score 0.80
- autosomal dominant vitreoretinochoroidopathy · score 0.76
- retinitis pigmentosa 50 · score 0.73
- retinitis pigmentosa · score 0.67
- Retinal dystrophy · score 0.57
- Stargardt disease · score 0.49
- adult-onset foveomacular vitelliform dystrophy · score 0.46
- MRCS syndrome · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76090-F1 | alphafold | PREDICTED | 71.86 | — |
Amino-acid sequence (585 residues)
MTITYTSQVA NARLGSFSRL LLCWRGSIYK LLYGEFLIFL LCYYIIRFIY RLALTEEQQL MFEKLTLYCD SYIQLIPISF VLGFYVTLVV TRWWNQYENL PWPDRLMSLV SGFVEGKDEQ GRLLRRTLIR YANLGNVLIL RSVSTAVYKR FPSAQHLVQA GFMTPAEHKQ LEKLSLPHNM FWVPWVWFAN LSMKAWLGGR IRDPILLQSL LNEMNTLRTQ CGHLYAYDWI SIPLVYTQVV TVAVYSFFLT CLVGRQFLNP AKAYPGHELD LVVPVFTFLQ FFFYVGWLKV AEQLINPFGE DDDDFETNWI VDRNLQVSLL AVDEMHQDLP RMEPDMYWNK PEPQPPYTAA SAQFRRASFM GSTFNISLNK EEMEFQPNQE DEEDAHAGII GRFLGLQSHD HHPPRANSRT KLLWPKRESL LHEGLPKNHK AAKQNVRGQE DNKAWKLKAV DAFKSAPLYQ RPGYYSAPQT PLSPTPMFFP LEPSAPSKLH SVTGIDTKDK SLKTVSSGAK KSFELLSESD GALMEHPEVS QVRRKTVEFN LTDMPEIPEN HLKEPLEQSP TNIHTTLKDH MDPYWALENR DEAHS
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