Fibroblast growth factor 18 (FGF18)

About Fibroblast growth factor 18

Fibroblast growth factor 18 (FGF18) is a protein from Homo sapiens identified by UniProt accession O76093, 207 residues long. MolForge cross-references it against 0 known binders and 347 disease associations.

Target properties

Protein name	Fibroblast growth factor 18
UniProt accession	O76093
Gene	FGF18
Organism	Homo sapiens
Length	207 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (347)

Diseases linked to this target (Open Targets).

cancer · score 0.60
bone development disease · score 0.59
lean body mass · score 0.50
body height · score 0.50
body weight · score 0.47
appendicular lean mass · score 0.45
PR interval · score 0.41
fat body mass · score 0.41
osteoarthritis, knee · score 0.39
forced expiratory volume · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O76093-F1	alphafold	PREDICTED	87.56	—

Amino-acid sequence (207 residues)

MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQPELQKPFK YTTVTKRSRR IRPTHPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards