Decapping and exoribonuclease protein (DXO)

About Decapping and exoribonuclease protein

Decapping and exoribonuclease protein (DXO) is a protein from Homo sapiens identified by UniProt accession O77932, 396 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Decapping and exoribonuclease protein
UniProt accession	O77932
Gene	DXO
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.10
psoriatic arthritis · score 0.10
C3a anaphylatoxin des arginine measurement · score 0.05
breast cancer · score 0.05
interleukin 18 receptor accessory protein measurement · score 0.05
monocyte count · score 0.05
self reported educational attainment · score 0.05
cognitive function measurement · score 0.05
von Willebrand factor measurement · score 0.04
complement C4 measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O77932-F1	alphafold	PREDICTED	92.66	—

Amino-acid sequence (396 residues)

MDPRGTKRGA EKTEVAEPRN KLPRPAPSLP TDPALYSGPF PFYRRPSELG CFSLDAQRQY HGDARALRYY SPPPTNGPGP NFDLRDGYPD RYQPRDEEVQ ERLDHLLCWL LEHRGRLEGG PGWLAEAIVT WRGHLTKLLT TPYERQEGWQ LAASRFQGTL YLSEVETPNA RAQRLARPPL LRELMYMGYK FEQYMCADKP GSSPDPSGEV NTNVAFCSVL RSRLGSHPLL FSGEVDCTDP QAPSTQPPTC YVELKTSKEM HSPGQWRSFY RHKLLKWWAQ SFLPGVPNVV AGFRNPDGFV SSLKTFPTMK MFEYVRNDRD GWNPSVCMNF CAAFLSFAQS TVVQDDPRLV HLFSWEPGGP VTVSVHQDAP YAFLPIWYVE AMTQDLPSPP KTPSPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards