About Unconventional prefoldin RPB5 interactor 1
Unconventional prefoldin RPB5 interactor 1 (URI1) is a protein
from Homo sapiens identified by UniProt accession
O94763, 535 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Unconventional prefoldin RPB5 interactor 1 |
|---|
| UniProt accession | O94763 |
|---|
| Gene | URI1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 535 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- mathematical ability · score 0.19
- urate measurement · score 0.16
- protein measurement · score 0.15
- cognitive function measurement · score 0.15
- hepatocellular carcinoma · score 0.11
- Miyoshi myopathy · score 0.08
- monocyte percentage of leukocytes · score 0.08
- neoplasm · score 0.08
- MODY · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94763-F1 | alphafold | PREDICTED | 62.01 | — |
Amino-acid sequence (535 residues)
MEAPTVETPP DPSPPSAPAP ALVPLRAPDV ARLREEQEKV VTNCQERIQH WKKVDNDYNA LRERLSTLPD KLSYNIMVPF GPFAFMPGKL VHTNEVTVLL GDNWFAKCSA KQAVGLVEHR KEHVRKTIDD LKKVMKNFES RVEFTEDLQK MSDAAGDIVD IREEIKCDFE FKAKHRIAHK PHSKPKTSDI FEADIANDVK SKDLLADKEL WARLEELERQ EELLGELDSK PDTVIANGED TTSSEEEKED RNTNVNAMHQ VTDSHTPCHK DVASSEPFSG QVNSQLNCSV NGSSSYHSDD DDDDDDDDDD DNIDDDDGDN DHEALGVGDN SIPTIYFSHT VEPKRVRINT GKNTTLKFSE KKEEAKRKRK NSTGSGHSAQ ELPTIRTPAD IYRAFVDVVN GEYVPRKSIL KSRSRENSVC SDTSESSAAE FDDRRGVLRS ISCEEATCSD TSESILEEEP QENQKKLLPL SVTPEAFSGT VIEKEFVSPS LTPPPAIAHP ALPTIPERKE VLLEASEETG KRVSKFKAAR LQQKD
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