About Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3) is a protein
from Homo sapiens identified by UniProt accession
O94766, 335 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 |
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| UniProt accession | O94766 |
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| Gene | B3GAT3 |
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| Organism | Homo sapiens |
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| Length | 335 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- Larsen-like syndrome, B3GAT3 type · score 0.80
- congenital heart disease · score 0.37
- Autosomal dominant Larsen syndrome · score 0.37
- genetic disorder · score 0.19
- body fat percentage · score 0.11
- appendicular lean mass · score 0.11
- triglyceride measurement · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- sex hormone-binding globulin measurement · score 0.09
- serum alanine aminotransferase measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94766-F1 | alphafold | PREDICTED | 92.56 | — |
Amino-acid sequence (335 residues)
MKLKLKNVFL AYFLVSIAGL LYALVQLGQP CDCLPPLRAA AEQLRQKDLR ISQLQAELRR PPPAPAQPPE PEALPTIYVV TPTYARLVQK AELVRLSQTL SLVPRLHWLL VEDAEGPTPL VSGLLAASGL LFTHLVVLTP KAQRLREGEP GWVHPRGVEQ RNKALDWLRG RGGAVGGEKD PPPPGTQGVV YFADDDNTYS RELFEEMRWT RGVSVWPVGL VGGLRFEGPQ VQDGRVVGFH TAWEPSRPFP VDMAGFAVAL PLLLDKPNAQ FDSTAPRGHL ESSLLSHLVD PKDLEPRAAN CTRVLVWHTR TEKPKMKQEE QLQRQGRGSD PAIEV
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