About Extracellular matrix protein 2
Extracellular matrix protein 2 (ECM2) is a protein
from Homo sapiens identified by UniProt accession
O94769, 699 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Extracellular matrix protein 2 |
|---|
| UniProt accession | O94769 |
|---|
| Gene | ECM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 699 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- body height · score 0.22
- creatinine measurement · score 0.14
- hemorrhoid · score 0.11
- BMI-adjusted waist circumference · score 0.10
- blood protein measurement · score 0.09
- lymphocyte count · score 0.09
- vital capacity · score 0.07
- BMI-adjusted waist-hip ratio · score 0.07
- triglyceride measurement · score 0.06
- appendicular lean mass · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94769-F1 | alphafold | PREDICTED | 71.30 | — |
Amino-acid sequence (699 residues)
MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK
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