About Aquaporin-8
Aquaporin-8 (AQP8) is a protein
from Homo sapiens identified by UniProt accession
O94778, 261 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | Aquaporin-8 |
|---|
| UniProt accession | O94778 |
|---|
| Gene | AQP8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (171)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- PHF-tau measurement · score 0.17
- smoking status measurement · score 0.13
- attention deficit hyperactivity disorder · score 0.12
- antisocial behaviour measurement · score 0.12
- substance abuse · score 0.12
- ulcerative colitis · score 0.07
- cyst · score 0.07
- primary ovarian insufficiency · score 0.07
- gestational diabetes · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94778-F1 | alphafold | PREDICTED | 91.28 | — |
Amino-acid sequence (261 residues)
MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF IGCLSVIENG TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM LIGGLNLVML LPYWVSQLLG GMLGAALAKA VSPEERFWNA SGAAFVTVQE QGQVAGALVA EIILTTLLAL AVCMGAINEK TKGPLAPFSI GFAVTVDILA GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL VGLLIRCFIG DGKTRLILKA R
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