Actin-like protein 6B (ACTL6B)

About Actin-like protein 6B

Actin-like protein 6B (ACTL6B) is a protein from Homo sapiens identified by UniProt accession O94805, 426 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	Actin-like protein 6B
UniProt accession	O94805
Gene	ACTL6B
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy · score 0.68
autosomal dominant non-syndromic intellectual disability · score 0.62
autism spectrum disorder · score 0.50
Intellectual disability · score 0.41
genetic disorder · score 0.41
complex neurodevelopmental disorder · score 0.37
undetermined early-onset epileptic encephalopathy · score 0.37
autism · score 0.32
Global developmental delay · score 0.27
breast adenocarcinoma · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O94805-F1	alphafold	PREDICTED	91.01	—

Amino-acid sequence (426 residues)

MSGGVYGGDE VGALVFDIGS FSVRAGYAGE DCPKADFPTT VGLLAAEEGG GLELEGDKEK KGKIFHIDTN ALHVPRDGAE VMSPLKNGMI EDWECFRAIL DHTYSKHVKS EPNLHPVLMS EAPWNTRAKR EKLTELMFEQ YNIPAFFLCK TAVLTAFANG RSTGLVLDSG ATHTTAIPVH DGYVLQQGIV KSPLAGDFIS MQCRELFQEM AIDIIPPYMI AAKEPVREGA PPNWKKKEKL PQVSKSWHNY MCNEVIQDFQ ASVLQVSDSP YDEQVAAQMP TVHYEMPNGY NTDYGAERLR IPEGLFDPSN VKGLSGNTML GVGHVVTTSI GMCDIDIRPG LYGSVIVTGG NTLLQGFTDR LNRELSQKTP PSMRLKLIAS NSTMERKFSP WIGGSILASL GTFQQMWISK QEYEEGGKQC VERKCP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards