About Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (GFPT2) is a protein
from Homo sapiens identified by UniProt accession
O94808, 682 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 |
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| UniProt accession | O94808 |
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| Gene | GFPT2 |
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| Organism | Homo sapiens |
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| Length | 682 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (108)
Diseases linked to this target (Open Targets).
- body height · score 0.40
- lean body mass · score 0.35
- airway imaging measurement · score 0.28
- body weights and measures · score 0.27
- urate measurement · score 0.24
- bone density · score 0.24
- BMI-adjusted waist circumference · score 0.17
- fat body mass · score 0.16
- appendicular lean mass · score 0.16
- whole body water mass · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94808-F1 | alphafold | PREDICTED | 92.51 | — |
Amino-acid sequence (682 residues)
MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNHEVK ERHIQLVKKR GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS AVNSHPQRSD KGNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSVH YPGEAVATRR GSPLLIGVRS KYKLSTEQIP ILYRTCTLEN VKNICKTRMK RLDSSACLHA VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAS DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR GALTVGVTNT VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL QNRRQEIIRG LRSLPELIKE VLSLEEKIHD LALELYTQRS LLVMGRGYNY ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE
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