Regulator of G-protein signaling 11 (RGS11)

About Regulator of G-protein signaling 11

Regulator of G-protein signaling 11 (RGS11) is a protein from Homo sapiens identified by UniProt accession O94810, 467 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Regulator of G-protein signaling 11
UniProt accession	O94810
Gene	RGS11
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin · score 0.53
mean corpuscular volume · score 0.36
mean corpuscular hemoglobin concentration · score 0.26
lung adenocarcinoma · score 0.23
head and neck squamous cell carcinoma · score 0.23
esophageal cancer · score 0.23
gastric adenocarcinoma · score 0.23
neurodegenerative disease · score 0.21
HbA1c measurement · score 0.21
erythrocyte count · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O94810-F1	alphafold	PREDICTED	86.11	—

Amino-acid sequence (467 residues)

MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards