About Tubulin polymerization-promoting protein
Tubulin polymerization-promoting protein (TPPP) is a protein
from Homo sapiens identified by UniProt accession
O94811, 219 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Tubulin polymerization-promoting protein |
|---|
| UniProt accession | O94811 |
|---|
| Gene | TPPP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 219 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (114)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.40
- serum urea measurement · score 0.29
- appendicular lean mass · score 0.27
- cystatin C measurement · score 0.24
- creatinine measurement · score 0.23
- blood urea nitrogen measurement · score 0.21
- serum alanine aminotransferase measurement · score 0.20
- hypertension · score 0.19
- FEV/FVC ratio · score 0.16
- peptic esophagitis · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94811-F1 | alphafold | PREDICTED | 78.15 | — |
Amino-acid sequence (219 residues)
MADKAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA LEEAFRRFAV HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF SKIKGKSCRT ITFEQFQEAL EELAKKRFKD KSSEEAVREV HRLIEGKAPI ISGVTKAISS PTVSRLTDTT KFTGSHKERF DPSGKGKGKA GRVDLVDESG YVSGYKHAGT YDQKVQGGK
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