About Ubiquitin-like protein ATG12
Ubiquitin-like protein ATG12 (ATG12) is a protein
from Homo sapiens identified by UniProt accession
O94817, 140 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Ubiquitin-like protein ATG12 |
|---|
| UniProt accession | O94817 |
|---|
| Gene | ATG12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 140 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (175)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- alkaline phosphatase measurement · score 0.24
- neoplasm · score 0.09
- renal cell carcinoma · score 0.09
- head and neck squamous cell carcinoma · score 0.08
- central corneal thickness · score 0.08
- low density lipoprotein particle size measurement · score 0.08
- intraocular pressure measurement · score 0.08
- melanoma · score 0.08
- hepatocellular carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94817-F1 | alphafold | PREDICTED | 78.88 | — |
Amino-acid sequence (140 residues)
MAEEPQSVLQ LPTSIAAGGE GLTDVSPETT TPEPPSSAAV SPGTEEPAGD TKKKIDILLK AVGDTPIMKT KKWAVERTRT IQGLIDFIKK FLKLVASEQL FIYVNQSFAP SPDQEVGTLY ECFGSDGKLV LHYCKSQAWG
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