About Kelch repeat and BTB domain-containing protein 11
Kelch repeat and BTB domain-containing protein 11 (KBTBD11) is a protein
from Homo sapiens identified by UniProt accession
O94819, 623 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 11 |
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| UniProt accession | O94819 |
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| Gene | KBTBD11 |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.42
- optic disc size measurement · score 0.12
- hemorrhagic disease · score 0.07
- Barrett's esophagus · score 0.06
- Testicular regression syndrome · score 0.05
- delta-6 desaturase measurement · score 0.05
- response to polyunsaturated fatty acid supplementation · score 0.05
- 46,XX gonadal dysgenesis · score 0.04
- ring chromosome Y · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94819-F1 | alphafold | PREDICTED | 73.84 | — |
Amino-acid sequence (623 residues)
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP PQSLASAAEG AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP EEPAAPSPEP RVWLEDPASP EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR LRAHKAVLAA RSDYFRARAS RDVLRVQGVS LTALRLLLAD AYSGRMAGVR PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL SAAKRQRLNE LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR GCGLCVLYNY LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ ARSQLRLLAL DGHLYAVGGE CLLSVERYDP RADRWAPVAP LPRGAFAVAH EATTCHGEIY VSGGSLFYRL LKYDPRRDEW QECPCSSSRE RSADMVALDG FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP LRLPGGPTGL QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV RGVLIPFALS LPEKPPRGEQ GAP
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