About Pleckstrin homology domain-containing family G member 5
Pleckstrin homology domain-containing family G member 5 (PLEKHG5) is a protein
from Homo sapiens identified by UniProt accession
O94827, 1006 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family G member 5 |
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| UniProt accession | O94827 |
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| Gene | PLEKHG5 |
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| Organism | Homo sapiens |
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| Length | 1006 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- neuronopathy, distal hereditary motor, autosomal recessive 4 · score 0.73
- Charcot-Marie-Tooth disease recessive intermediate C · score 0.72
- Autosomal recessive intermediate Charcot-Marie-Tooth disease type C · score 0.60
- genetic disorder · score 0.50
- juvenile amyotrophic lateral sclerosis · score 0.41
- neuromuscular disease · score 0.37
- neurodegenerative disease · score 0.37
- spinal muscular atrophy, facioscapulohumeral type · score 0.33
- hereditary spastic paraplegia · score 0.26
- breast adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94827-F1 | alphafold | PREDICTED | 63.57 | — |
Amino-acid sequence (1006 residues)
MHYDGHVRFD LPPQGSVLAR NVSTRSCPPR TSPAVDLEEE EEESSVDGKG DRKSTGLKLS KKKARRRHTD DPSKECFTLK FDLNVDIETE IVPAMKKKSL GEVLLPVFER KGIALGKVDI YLDQSNTPLS LTFEAYRFGG HYLRVKAPAK PGDEGKVEQG MKDSKSLSLP ILRPAGTGPP ALERVDAQSR RESLDILAPG RRRKNMSEFL GEASIPGQEP PTPSSCSLPS GSSGSTNTGD SWKNRAASRF SGFFSSGPST SAFGREVDKM EQLEGKLHTY SLFGLPRLPR GLRFDHDSWE EEYDEDEDED NACLRLEDSW RELIDGHEKL TRRQCHQQEA VWELLHTEAS YIRKLRVIIN LFLCCLLNLQ ESGLLCEVEA ERLFSNIPEI AQLHRRLWAS VMAPVLEKAR RTRALLQPGD FLKGFKMFGS LFKPYIRYCM EEEGCMEYMR GLLRDNDLFR AYITWAEKHP QCQRLKLSDM LAKPHQRLTK YPLLLKSVLR KTEEPRAKEA VVAMIGSVER FIHHVNACMR QRQERQRLAA VVSRIDAYEV VESSSDEVDK LLKEFLHLDL TAPIPGASPE ETRQLLLEGS LRMKEGKDSK MDVYCFLFTD LLLVTKAVKK AERTRVIRPP LLVDKIVCRE LRDPGSFLLI YLNEFHSAVG AYTFQASGQA LCRGWVDTIY NAQNQLQQLR AQEPPGSQQP LQSLEEEEDE QEEEEEEEEE EEEGEDSGTS AASSPTIMRK SSGSPDSQHC ASDGSTETLA MVVVEPGDTL SSPEFDSGPF SSQSDETSLS TTASSATPTS ELLPLGPVDG RSCSMDSAYG TLSPTSLQDF VAPGPMAELV PRAPESPRVP SPPPSPRLRR RTPVQLLSCP PHLLKSKSEA SLLQLLAGAG THGTPSAPSR SLSELCLAVP APGIRTQGSP QEAGPSWDCR GAPSPGSGPG LVGCLAGEPA GSHRKRCGDL PSGASPRVQP EPPPGVSAQH RKLTLAQLYR IRTTLLLNST LTASEV
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