About Triacylglycerol hydrolase DDHD2
Triacylglycerol hydrolase DDHD2 (DDHD2) is a protein
from Homo sapiens identified by UniProt accession
O94830, 711 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Triacylglycerol hydrolase DDHD2 |
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| UniProt accession | O94830 |
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| Gene | DDHD2 |
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| Organism | Homo sapiens |
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| Length | 711 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (83)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 54 · score 0.79
- hereditary spastic paraplegia 54 · score 0.76
- complex hereditary spastic paraplegia · score 0.55
- hereditary spastic paraplegia · score 0.47
- genetic disorder · score 0.41
- Global developmental delay · score 0.34
- generalised epilepsy · score 0.34
- obesity · score 0.34
- systolic blood pressure · score 0.34
- diastolic blood pressure · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94830-F1 | alphafold | PREDICTED | 73.69 | — |
Amino-acid sequence (711 residues)
MSSVQSQQEQ LSQSDPSPSP NSCSSFELID MDAGSLYEPV SPHWFYCKII DSKETWIPFN SEDSQQLEEA YSSGKGCNGR VVPTDGGRYD VHLGERMRYA VYWDELASEV RRCTWFYKGD KDNKYVPYSE SFSQVLEETY MLAVTLDEWK KKLESPNREI IILHNPKLMV HYQPVAGSDD WGSTPTEQGR PRTVKRGVEN ISVDIHCGEP LQIDHLVFVV HGIGPACDLR FRSIVQCVND FRSVSLNLLQ THFKKAQENQ QIGRVEFLPV NWHSPLHSTG VDVDLQRITL PSINRLRHFT NDTILDVFFY NSPTYCQTIV DTVASEMNRI YTLFLQRNPD FKGGVSIAGH SLGSLILFDI LTNQKDSLGD IDSEKDSLNI VMDQGDTPTL EEDLKKLQLS EFFDIFEKEK VDKEALALCT DRDLQEIGIP LGPRKKILNY FSTRKNSMGI KRPAPQPASG ANIPKESEFC SSSNTRNGDY LDVGIGQVSV KYPRLIYKPE IFFAFGSPIG MFLTVRGLKR IDPNYRFPTC KGFFNIYHPF DPVAYRIEPM VVPGVEFEPM LIPHHKGRKR MHLELREGLT RMSMDLKNNL LGSLRMAWKS FTRAPYPALQ ASETPEETEA EPESTSEKPS DVNTEETSVA VKEEVLPINV GMLNGGQRID YVLQEKPIES FNEYLFALQS HLCYWESEDT VLLVLKEIYQ TQGIFLDQPL Q
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