About TOX high mobility group box family member 4
TOX high mobility group box family member 4 (TOX4) is a protein
from Homo sapiens identified by UniProt accession
O94842, 621 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | TOX high mobility group box family member 4 |
|---|
| UniProt accession | O94842 |
|---|
| Gene | TOX4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 621 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- lean body mass · score 0.19
- fat body mass · score 0.16
- body weight · score 0.15
- body height · score 0.13
- base metabolic rate measurement · score 0.12
- whole body water mass · score 0.11
- acute myeloid leukemia · score 0.07
- MODY · score 0.04
- self reported educational attainment · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94842-F1 | alphafold | PREDICTED | 54.71 | — |
Amino-acid sequence (621 residues)
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS SQLGLSLGGG TILPPAQSPE DRLSTTPSPT SSLHEDGVED FRRQLPSQKT VVVEAGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV ETVELDPAPP SQTPSPPPMA TVDPASPAPA SIEPPALSPS IVVNSTLSSY VANQASSGAG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL QLGQTSTATI QPSQQAQIVT RSVLQAAAAA AAAASMQLPP PRLQPPPLQQ MPQPPTQQQV TILQQPPPLQ AMQQPPPQKV RINLQQQPPP LQIKSVPLPT LKMQTTLVPP TVESSPERPM NNSPEAHTVE APSPETICEM ITDVVPEVES PSQMDVELVS GSPVALSPQP RCVRSGCENP PIVSKDWDNE YCSNECVVKH CRDVFLAWVA SRNSNTVVFV K
Explore TOX high mobility group box family member 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets