About Rho-related BTB domain-containing protein 1
Rho-related BTB domain-containing protein 1 (RHOBTB1) is a protein
from Homo sapiens identified by UniProt accession
O94844, 696 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Rho-related BTB domain-containing protein 1 |
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| UniProt accession | O94844 |
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| Gene | RHOBTB1 |
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| Organism | Homo sapiens |
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| Length | 696 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- bone density · score 0.33
- urate measurement · score 0.33
- PHF-tau measurement · score 0.27
- diet measurement · score 0.25
- hair shape measurement · score 0.23
- alopecia · score 0.20
- body mass index · score 0.11
- balding measurement · score 0.10
- drug use measurement · score 0.08
- thyroid cancer, nonmedullary, 1 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94844-F1 | alphafold | PREDICTED | 82.12 | — |
Amino-acid sequence (696 residues)
MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKS MWYPEIKHFC PRTPVILVGC QLDLRYADLE AVNRARRPLA RPIKRGDILP PEKGREVAKE LGLPYYETSV FDQFGIKDVF DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKIPECPS MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN KSLVEALGLE AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV RMDASVQPGP FRTLLQFLYT GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE NIMNKEAFMN QEITKAFHVR KANRIKECLS KGTFSDVTFK LDDGAISAHK PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL DYLYTKQLSP NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR WPPVWYLKEE DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA
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