About Dendrin
Dendrin (DDN) is a protein
from Homo sapiens identified by UniProt accession
O94850, 711 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Dendrin |
|---|
| UniProt accession | O94850 |
|---|
| Gene | DDN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 711 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.64
- self reported educational attainment · score 0.29
- cognitive function measurement · score 0.25
- reaction time measurement · score 0.24
- bone quantitative ultrasound measurement · score 0.22
- intelligence · score 0.19
- bone density · score 0.16
- osteoporosis · score 0.14
- age at menarche · score 0.14
- schizophrenia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94850-F1 | alphafold | PREDICTED | 45.79 | — |
Amino-acid sequence (711 residues)
MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP SRQPMDFQAS HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG PLAEVRAREQ EKRKAASQER EAKETERKRR KAGGARRSPP GRPRPEPRNA PRVAQLAGLP APLRPERLAP VGRAPRPSAQ PQSDPGSAWA GPWGGRRPGP PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL GTKRGPGNSQ VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS ATAAPCAPHP APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT LPRPWAPGGT GWRESLGLGE GAGPETLEGW KATRRAHTLP RSSQGLSRGE GVFVIDATCV VIRSQYVPTP RTQQVQLLPS GVTRVVGDSP SQSKPGKEEG EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST LEERTFRILG LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG ASWRNERTLP EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI RGTQQGNRKR Q
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