About FERM, ARHGEF and pleckstrin domain-containing protein 2
FERM, ARHGEF and pleckstrin domain-containing protein 2 (FARP2) is a protein
from Homo sapiens identified by UniProt accession
O94887, 1054 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | FERM, ARHGEF and pleckstrin domain-containing protein 2 |
|---|
| UniProt accession | O94887 |
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| Gene | FARP2 |
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| Organism | Homo sapiens |
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| Length | 1054 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- eosinophil count · score 0.34
- fibrinogen measurement · score 0.29
- high density lipoprotein cholesterol measurement · score 0.29
- C-reactive protein measurement · score 0.28
- triglyceride measurement · score 0.28
- eosinophil percentage of leukocytes · score 0.27
- apolipoprotein B measurement · score 0.26
- urate measurement · score 0.25
- apolipoprotein A 1 measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94887-F1 | alphafold | PREDICTED | 74.63 | — |
Amino-acid sequence (1054 residues)
MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL LDNTMEIFDI EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE PMKPIIRQIR RPKNVVLRLA VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCADTTA ALLTSHLLQS EIGDYDETLD REHLKVNEYL PGQQHCLEKI LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE GTKIQLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYFKDSGM KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP SSANAFYSLS PSTLVPSGLP EFKDSSSSLT DPQVSYVKSP AAERRSGAVA GGPDTPSAQP LGPPALQPGP GLSTKSPQPS PSSRKSPLSL SPAFQVPLGP AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV KEILATERTY LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR LALWEGPSKA HTKGSHQRIG DILLRNMRQL KEFTSYFQRH DEVLTELEKA TKRCKKLEAV YKEFELQKVC YLPLNTFLLK PIQRLLHYRL LLRRLCGHYS PGHHDYADCH DALKAITEVT TTLQHILIRL ENLQKLTELQ RDLVGIENLI APGREFIREG CLHKLTKKGL QQRMFFLFSD MLLYTSKGVA GTSHFRIRGL LPLQGMLVEE SDNEWSVPHC FTIYAAQKTI VVAASTRLEK EKWMLDLNSA IQAAKSGGDT APALPGRTVC TRPPRSPNEV SLEQESEDDA RGVRSSLEGH GQHRANTTMH VCWYRNTSVS RADHSAAVEN QLSGYLLRKF KNSHGWQKLW VVFTNFCLFF YKTHQDDYPL ASLPLLGYSV SIPREADGIH KDYVFKLQFK SHVYFFRAES KYTFERWMEV IQGASSSAGR APSIVQDGPQ PSSGLEGMVR GKEE
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