Kelch-like protein 18 (KLHL18)

About Kelch-like protein 18

Kelch-like protein 18 (KLHL18) is a protein from Homo sapiens identified by UniProt accession O94889, 574 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Kelch-like protein 18
UniProt accession	O94889
Gene	KLHL18
Organism	Homo sapiens
Length	574 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

body height · score 0.35
triglyceride measurement · score 0.15
heel bone mineral density · score 0.13
reticulocyte count · score 0.13
serum non-albumin protein measurement · score 0.12
body mass index · score 0.10
urate measurement · score 0.10
eosinophil percentage of leukocytes · score 0.08
bilirubin measurement · score 0.08
deafness · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O94889-F1	alphafold	PREDICTED	93.35	—

Amino-acid sequence (574 residues)

MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS AHRIVLAASI PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN LAIDQQNVQS LLMGASFLQL QSIKDACCTF LRERLHPKNC LGVRQFAETM MCAVLYDAAN SFIHQHFVEV SMSEEFLALP LEDVLELVSR DELNVKSEEQ VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR VQQDDLVRCC HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL STVEAYNPET DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV ETYSPETDKW TVVTSMSSNR SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY NHHTATWHPA AGMLNKRCRH GAASLGSKMF VCGGYDGSGF LSIAEMYSSV ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS VEMYDPETDC WTFMAPMACH EGGVGVGCIP LLTI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards