About Thymocyte selection-associated high mobility group box protein TOX
Thymocyte selection-associated high mobility group box protein TOX (TOX) is a protein
from Homo sapiens identified by UniProt accession
O94900, 526 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | Thymocyte selection-associated high mobility group box protein TOX |
|---|
| UniProt accession | O94900 |
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| Gene | TOX |
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| Organism | Homo sapiens |
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| Length | 526 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (294)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Myopia · score 0.43
- refractive error · score 0.41
- smoking initiation · score 0.40
- wellbeing measurement · score 0.39
- alcohol consumption measurement · score 0.39
- adolescent idiopathic scoliosis · score 0.39
- smoking status measurement · score 0.38
- Hypermetropia · score 0.37
- smoking behavior · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94900-F1 | alphafold | PREDICTED | 54.39 | — |
Amino-acid sequence (526 residues)
MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD YVPASQSYPG PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM NHNGLLPFHP QNMDLPEITV SNMLGQDGTL LSNSISVMPD IRNPEGTQYS SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT TINQSQLSAQ LGLNMGGSNV PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA SDMGKKPKTP KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ LINSKPSVFH GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP NNQMPVTVSI ANMAVSPPPP LQISPPLHQH LNMQQHQPLT MQQPLGNQLP MQVQSALHSP TMQQGFTLQP DYQTIINPTS TAAQVVTQAM EYVRSGCRNP PPQPVDWNND YCSSGGMQRD KALYLT
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