About Pyridoxal phosphate homeostasis protein
Pyridoxal phosphate homeostasis protein (PLPBP) is a protein
from Homo sapiens identified by UniProt accession
O94903, 275 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Pyridoxal phosphate homeostasis protein |
|---|
| UniProt accession | O94903 |
|---|
| Gene | PLPBP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- pyridoxine-dependent epilepsy · score 0.72
- genetic disorder · score 0.41
- body height · score 0.12
- triglyceride measurement · score 0.12
- type 2 diabetes mellitus · score 0.11
- reticulocyte count · score 0.10
- leukocyte count · score 0.09
- lymphocyte count · score 0.09
- drug use measurement · score 0.04
- protein measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94903-F1 | alphafold | PREDICTED | 89.34 | — |
Amino-acid sequence (275 residues)
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ NVNKLMAVPN LFMLETVDSV KLADKVNSSW QRKGSPERLK VMVQINTSGE ESKHGLPPSE TIAIVEHINA KCPNLEFVGL MTIGSFGHDL SQGPNPDFQL LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV RIGSTIFGER DYSKKPTPDK CAADVKAPLE VAQEH
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