About Erlin-2
Erlin-2 (ERLIN2) is a protein
from Homo sapiens identified by UniProt accession
O94905, 339 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Erlin-2 |
|---|
| UniProt accession | O94905 |
|---|
| Gene | ERLIN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 339 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 18 · score 0.74
- hereditary spastic paraplegia 18 · score 0.71
- hereditary spastic paraplegia · score 0.63
- cancer · score 0.59
- bone development disease · score 0.56
- Spastic paraplegia · score 0.54
- Neurodegeneration · score 0.46
- cystic fibrosis · score 0.46
- Intellectual disability · score 0.37
- juvenile primary lateral sclerosis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94905-F1 | alphafold | PREDICTED | 85.13 | — |
Amino-acid sequence (339 residues)
MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPNAV YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF LAREKAKADA ECYTAMKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD IPNMFMDSAG SVSKQFEGLA DKLSFGLEDE PLETATKEN
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