About Dickkopf-related protein 1
Dickkopf-related protein 1 (DKK1) is a protein
from Homo sapiens identified by UniProt accession
O94907, 266 residues long.
MolForge cross-references it against 0 known binders and
619 disease associations.
Target properties
| Protein name | Dickkopf-related protein 1 |
|---|
| UniProt accession | O94907 |
|---|
| Gene | DKK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 266 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (619)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.41
- dickkopf‐related protein 1 measurement · score 0.38
- blood protein measurement · score 0.38
- Arnold-Chiari malformation type I · score 0.37
- QRS complex · score 0.33
- tuberculosis · score 0.31
- Dickkopf-related protein 4 measurement · score 0.30
- sitting height measurement · score 0.29
- Behcet's syndrome · score 0.28
- heart function measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94907-F1 | alphafold | PREDICTED | 69.95 | — |
Amino-acid sequence (266 residues)
MMALGAAGAT RVFVAMVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG GAAGHPGSAV SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH TKGQEGSVCL RSSDCASGLC CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG EGLSCRIQKD HHQASNSSRL HTCQRH
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