Adhesion G protein-coupled receptor L1 (ADGRL1)

About Adhesion G protein-coupled receptor L1

Adhesion G protein-coupled receptor L1 (ADGRL1) is a protein from Homo sapiens identified by UniProt accession O94910, 1474 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Adhesion G protein-coupled receptor L1
UniProt accession	O94910
Gene	ADGRL1
Organism	Homo sapiens
Length	1474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

Global developmental delay · score 0.52
attention deficit hyperactivity disorder · score 0.50
genetic disorder · score 0.50
Autistic behavior · score 0.49
Intellectual disability · score 0.49
Specific learning disability · score 0.43
Seizure · score 0.43
complex neurodevelopmental disorder · score 0.37
Neurodevelopmental disorder · score 0.12
Obesity · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O94910-F1	alphafold	PREDICTED	69.59	—

Amino-acid sequence (1474 residues)

MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP VPSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE EYPRKNSIQL SAKTIKQNSR NGVVKVVFIL YNNLGLFLST ENATVKLAGE AGPGGPGGAS LVVNSQVIAA SINKESSRVF LMDPVIFTVA HLEDKNHFNA NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN FAVLMAHREI YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL LLVEVFESEY SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD NYFIWSFIGP VSFVIVVNLV FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA LGAIALLFLL GLTWAFGLLF INKESVVMAY LFTTFNAFQG VFIFVFHCAL QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR YYTGTQSRIR RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN SYSLRSGDFP PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA KGPPPPEPPV PPVPGGGGEE EAGGPGGADR AEIELLYKAL EEPLLLPRAQ SVLYQSDLDE SESCTAEDGA TSRPLSSPPG RDSLYASGAN LRDSPSYPDS SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY YQVRRPSHEG YLAAPGLEGP GPDGDGQMQL VTSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards